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Low doses of aspirin also showed an effect of induction of CYP2C19. The impact of the order soma tabs Kansas City potential exposure of changes in terms of drug efficacy or safety order soma tabs Kansas City of carisoprodol is unknown. Pregnancy There are no data on the use of carisoprodol pregnancy. Animal studies indicate that carisoprodol crosses the placenta and causes adverse effects on fetal growth and postnatal survival. The major metabolite of carisoprodol, meprobamate, is an approved anxiolytic. Retrospective, post-marketing studies order soma tabs Kansas City do not show a consistent association between maternal consumption of meprobamate and an increased risk of birth defects in particular.

Teratogenic effects: Animal studies have not adequately evaluated the teratogenic effects of carisoprodol. There was no increased incidence of congenital order soma tabs Kansas City malformations noted in reproductive studies in rats, rabbits and mice treated with meprobamate. Retrospective, post-marketing studies of meprobamate during human pregnancy are equivocal order soma tabs Kansas City for demonstrating an increased risk of birth defects following exposure during the first quarter. Among the studies that have shown an increased risk of malformations incompatible types. Teratogenic effects: In animal studies, carisoprodol reduced fetal weights, weight gain after birth, survivaland postnatal maternal dose equivalent to 11.5 times the human dose (based on a comparison of body surface). Rats exposed to meprobamate uteroshowed disorders that persists into adulthood. For children exposed in utero to meprobamate, a study found no order soma tabs Kansas City negative effects on mental development or motor ouQI. Carisoprodol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. No information on the effects of carisoprodol in the mother and fetus during labor. Very limited data in humans indicate order soma tabs Kansas City that carisoprodol is present in breast milk and may reach concentrations two to four times the levels of maternal plasma. In one case, an infant received approximately 46% of the maternal daily dose through order soma tabs Kansas City breast milk and experienced no adverse effects. However, milk production was inadequate and that the baby was supplemented with formula. In studies of lactation in mice, the survival of women and newborn pup weight at weaning was reduced. These data suggest that maternal use of carisoprodol may lead to the reduction order soma tabs Kansas City of infant feeding or less effective (because lasedación) and / or decreased order soma tabs Kansas City milk production.

Caution should be exercised when administered to a nursing mother carisoprodol. The efficacy, safety and pharmacokinetics of carisoprodol in pediatric patients under 16 years have not been established. The efficacy, safety and pharmacokinetics of carisoprodol in patients over order soma tabs Kansas City 65 have not been established. The safety and pharmacokinetics of carisoprodol in patients with renal impairment have not been evaluated. Since carisoprodol is excreted by the kidneys, caution should be exercised if carisoprodol is order soma tabs Kansas City administered to patients with renal failure. Carisoprodol is dialyzable by hemodialysis and peritoneal dialysis.

The safety and pharmacokinetics of carisoprodol in patients with hepatic impairment have not been evaluated. Since carisoprodol is metabolized in the order soma tabs Kansas City liver, caution should be exercised if carisoprodol is administered to patients order soma tabs Kansas City with liver failure. Patients with reduced activity CYP2C19 have higher exposure to carisoprodol. Therefore, caution should be exercised in the administration of carisoprodol in these patients [see Clinical Pharmacology (12.3)]. [See Warnings order soma tabs Kansas City and Precautions (5.2)] carisoprodol overdose generally produce CNS depression. Death, coma, respiratory depression, hypotension, convulsions, delirium, hallucinations, dystonic reactions, nystagmus, blurred vision, mydriasis, euphoria, muscular incoordination, rigidity and / or headache have been reported with carisoprodol overdose. Many carisoprodol overdose took place as part of a multiple drug overdose (including order soma tabs Kansas City drug abuse, illicit drugs and alcohol).